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The addition of an N-terminal C20 fatty acid on cagrilintide prolongs the half-life of this medication compared to the first-generation drug, pramlintide
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doi: 10.1007/s40610-020-00140-1
The cagrilintide arm is an acylated, long-acting analog of amylin a peptide co-secreted with insulin by pancreatic beta cells associated with slowed gastric emptying, suppressed post-meal glucagon, and satiety via distinct hindbrain pathways [7]
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