These findings have not been confirmed in large-scale human trials
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10.1104/pp.122.3.793 Plant Physiol
Patients often experience side effects (for example, persistent cough with ACE inhibitors or muscle pain with high-dose statins), issues with adherence, and even drug resistance or tolerance over time
Third, analogs of FGF21 and FGF19 appear to reduce markers of liver injury (ALT) and fibrosis (Pro-C3) to a similar extent in humans (245, 306), consistent with FGFR4 agonism not being required in vivo , while being associated with an undesirable increase in LDL-C