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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 2% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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This process is considered one of the primary biomarkers of biological aging, and shorter telomere length is associated with increased risk of age-related disease

This range appears to optimize bone health, immune function, and other vitamin D-dependent processes while minimizing risks of both deficiency and excess

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