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Reduced apoptosis is often associated with the development of cancer, and finding agents that can restore programmed cell death in cancer cells is considered a potential therapy for cancer

During initiation, cells export reduced GSH through plasma membrane transporters before membrane rupture, establishing a redox environment permissive for apoptotic signaling

Signs of elevated levels of glutathione after the first weeks use include improvements in energy levels, skin brightening, and a visible glow all over

Based on these findings, we ultimately culminate a rational design of a liposomal apparatus integrating oridonin, maleimide, and TLR2 targeting peptide for GSH depletion and specific cancer cells delivery

Subsequently, NP4-Cy7.5 was intravenously injected into BALB/c mice, and the biodistribution of nanoparticles in mice was observed using an in vivo imaging system (IVIS)