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One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation
When you take B12 as an injection, you need to have a doctors prescription in order to ensure that there are no harmful interactions with other medications
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Individual factors such as metabolic rate, body weight, and age may theoretically influence how B12 is distributed and utilised, though evidence for their impact on injection intervals is limited
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