The results of a 6-month stability test for selected formulations in 40C oven (accelerated stability test for a product intended for storage at room temperature), and room temperature (25C) (accelerated stability test for a product intended for storage in a refrigerator) are shown in Figure 1 and Figure 2, respectively
Dihexa or its analogs were administered 5 minutes after scopolamine, either intracerebroventricularly at doses of 0.1 or 1 nmol), intraperitoneally at doses of 0.05, 0.25, or 0.50 mg/kg, or orally at doses of 1.25 or 2.0 mg/kg
This represents complementary rather than redundant mechanisms
Using conservative doses for reasonable durations with breaks between cycles represents a prudent approach to risk management
Therefore, careful patient stratification and the development of biomarkers to distinguish pathological from compensatory angiogenesis are crucial