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Am J Gastroenterol 2011

The cleanest ex vivo human-follicle-elongation evidence came from AHK-Cu, not GHK-Cu, and applying it to GHK-Cu is inference, not demonstration

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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females