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However, when the investigational drug presents a higher level of risk for example in certain oncology settings, where the compound may be too toxic for healthy subjects the study may involve patients instead

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These include senolytics, which aim to block the transition of cells into a senescent state, and senoreversers, which promote the exit of senescent cells from this state [99]

A 250 mcg dose then requires only 2.5 syringe units, which is below the reliable measurement threshold for U-100 syringes

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