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Cytosol of the different strains was obtained by centrifugation at 1.500 g for 10 min at 4C, and suspension in 0.5 M Tris/HCl buffer (pH 6.8) 1 mM EDTA

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Microchips were inserted subcutaneously in the lower abdominal region under general anaesthesia 1 wk before testing

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The vast majority of the human and animal data we have on epithalon the lifespan studies, the telomerase upregulation studies, the immune and cardiovascular outcomes was conducted using base epithalon or epithalamin, at the higher doses