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Distinct variabilities of infection rates, epidemiological transmission, and clinical outcomes during COVID-19 pandemic raises an intriguing question, whether the emergence of SARS-CoV-2 variants of concern (VOCs) with function-specific mutations in ACE2, furin, and TMPRSS2 expression has played any role in disease manifestations and case fatality rates (CFR) 55,75

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This also introduces the question of how to treat COVID-19 patients with pre-existing SLE

The therapeutic activity of NAC has been extensively investigated in in vitro and in vivo studies and, consequently, it has been used clinically for more than 50 years [12]