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Erythrocytes affect hemostasis and thrombosis by altering blood viscosity, blood flow dynamics, secreting RBC-derived microvesicles, interactions with platelets or endothelial cells, fibrinogen-induced RBC aggregation, activation of blood coagulation factors, direct modulation of thrombin and fibrin formation, or formation of polyhedral-like erythrocytes in thrombi [47,48,49]

Gastrointestinal distress affects roughly 28% of users at higher doses, with nausea being the most commonly reported complaint

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Angiogenic signaling is a recurring theme in this area because vascular development plays an essential role in delivering oxygen, nutrients, and osteogenic precursor cells to healing bone tissue