As of the time of writing, 22 human UGT proteins can be distinguished: UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2A1, UGT2A2, UGT2A3, UGT2B4, UGT2B7, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT3A1, UGT3A2, and UGT8A1 (Mackenzie et al., 2008, Miners et al., 2006,Court et al., 2004, Patten, 2006, Sneitz et al., 2009)
Renal function: Dehydration secondary to gastrointestinal side effects can impair renal function, particularly in those with pre-existing kidney disease
Its research profile makes it especially relevant for studies focused on sleep architecture, stress adaptation, hypothalamic-pituitary signaling, and nervous-system recovery models
WS: Writing original draft, Writing review & editing
Funding Supported by the grant from the Medical University of Lodz (#503/1-156-04/503-11-001 to JF)