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10.1093/femsyr/foy024 55 ChakravarthiS.JessopC

In myeloid cell lines there was a more differential effect: when quercetin and apigenin were used in combination with each topoisomerase II inhibitor, there was a synergistic/additive decrease in cell proliferation, cell accumulation in G 2 M and S phase of the cell cycle and an increase in apoptosis

A., Fletcher, M., Hollinghurst, S., & Peters, T

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Although further prospective randomized trials are required, these strong associations together confirm that ICI treatment combined with statins in NSCLC patients may remarkably improve survival and prognosis, suggesting that the antitumor functions of statins synergize the benefits of ICI therapy in prevalent lung cancer