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The mechanism likely involves stress reduction (lowering cortisol that suppresses BDNF) combined with attentional training that directly engages BDNF-dependent hippocampal and prefrontal circuits

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Berberine protects against dopamine depletion and -synuclein upregulation, as reported in previous studies, this finding was correlated with the improvement of the number of normal dopaminergic nerves observed in both groups with preference to BER chitosome group [23, 96]

Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment