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Conversely, the extrinsic pathway of apoptosis is initiated by the binding of death ligands to death receptors, which activates downstream effector caspase-8, ultimately resulting in the activation of caspase-3, -6, and 7, thereby inducing direct cell death [94]

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This occurs when brain neurons are damaged, in some cases so badly that they die

The glucagon-like peptide-1 agonists (GLP-1s) class of weight-loss drugs, which includes medications like tirzepatide and semaglutide, have been shown to reduce body fat in large clinical trials