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Caloric restriction has been shown to extend lifespan and delay the onset of age-related chronic diseases in a variety of species, including rats, mice, fish, flies, worms, and yeast

However, B12 supplements will most likely increase energy levels in those who are deficient, as this nutrient plays an important role in converting food into energy

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[iii] Even with careful planning and preclinical data collection, there are inherent risks and challenges associated with first-in-human clinical trials