It rests on NAD+ decline being an aging driver and on MOTS-c extending healthspan in mice [1][3]
One study investigating these effects in obese mice discovered that administration of an NNMT blocker reduced insulin serum levels by 50-60% in the subjects
Significant main effects of treatment group (prior to BenjaminiHochberg correction since none were significant after correction, although the necessity of correction for multiple comparisons in exploratory analyses remains unresolved 49 ) were observed for the unclassified group and ten classified genera, namely, Acetatifactor , Akkermansia , Erysipelatoclostridium , [ Eubacterium ] coprostanoligenes group , Family XIII UCG-001 , Lactobacillus , Parasutterella , Ruminiclostridium 6 , Ruminococcaceae UCG-004 , and Ruminococcaceae UCG-009
Preventing B12 deficiency If you're at risk for vitamin B12 deficiency, the following can provide some protection: Supplements
Studies indicate possible nootropic effects through enhanced cellular energy metabolism, improved mitochondrial function, and reduced oxidative stress
