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The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth

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if a duct is blocked (by a gallstone, scar-like narrowing/stricture, or a tumor), the drug cant reach its target and adding more bile acids can worsen the backup (jaundice, itching, rising bilirubin/ALP)

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Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats