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The titration protocol exists because GLP-1 receptor agonists cause gastrointestinal side effects, primarily nausea, that are dose-dependent

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N-acetylcysteine, or NAC, is a supplement that works in two ways: It provides cysteine, which is the rate-limiting amino acid for glutathione production It can also act as a direct antioxidant to scavenge ROS (NO2 and HOX)[ref][ref] The main antioxidant mechanism for NAC is by increasing glutathione levels