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Common side effects include: Nausea and vomiting Diarrhoea or constipation Reduced appetite (which is also a therapeutic effect) Injection site reactions (redness, bruising, or mild discomfort) These effects are typically mild to moderate and tend to resolve as the body adjusts to the medication

10.1038/s41574-023-00874-9 30 CuiY.ZhangN

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Junyu Zhao, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers