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The dynamin-related protein (Drp-1) and its mitochondrial adaptor fission protein 1 (Fis-1) are the main responsible for mitochondrial fission, a process positively related to mitochondrial fragmentation and apoptosis ( in vitro and in the rat hippocampus, leading to decreased elongated mitochondria, abnormal cristae depletion, apoptosis, and consequently loss of NSPCs proliferation/differentiation balance

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- (1,3)-glucosidases act on the non-reducing ends of - (1,3)-glucans and discharge glucose from oligosaccharides (64)

This method allows for targeted treatment of specific areas, making it an appealing option for those with localized hyperpigmentation