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The crucial role of glutamine in macrophages has been emphasized through early animal experiments, which have unveiled its irreplaceable involvement in cytokine generation, including prominent players like IL-1, IL-6, and tumour necrosis factor (TNF)- [124]

Overexpression of angiotensin converting enzyme 2 reduces anxiety-like behavior in female mice

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However, under prolonged high-glucose exposure insulin secretion is impaired in aged (50 wo) Taz -KD islets, suggesting an increased vulnerability to glucotoxic stress over time