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Metabolic Consequences of Folate Insufficiency The effects of folate deficiency on the methionine cycle have widespread metabolic consequences, including: Altered DNA Methylation Patterns Insufficient folate reduces the availability of methyl groups for DNA methylation, leading to epigenetic instability

Cardiac causes of hypoxia in sickle cell disease

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It plays a key role in metabolic pathways such as glycolysis, the citric acid cycle, and oxidative phosphorylation, while also maintaining cellular function and promoting repair processes

Therefore, in our transcriptomic analysis, special interests were paid to pathways of carbon metabolism, lipid metabolism (glycerophospholipid) and DNA biosynthesis (including cell cycle, DNA replication and purine/pyrimidine metabolism)