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Sung LC, Chao HH, Chen CH et al (2015) Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells

, Although the rate of glutathione synthesis depends on cysteine availability, cysteine is quickly oxidized to its dimer form cystine in the extracellular space (Figure 1E)

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Injectable administration likely achieves higher blood concentrations, though comparative human data does not exist