[124] Other causes of B 12 malabsorption include bariatric surgery, pancreatic insufficiency, obstructive jaundice, tropical sprue, celiac disease, inherited intrinsic factor deficiency, and radiation enteritis affecting the distal ileum
That is the proposed reason it does not raise IGF-1 levels or impair insulin sensitivity in animal work, in contrast to full-length growth hormone
People with dietary restrictions, such as vegans and vegetarians, who may not get sufficient B12 from their diet, or those with absorption issues, like those with pernicious anemia or gastrointestinal disorders, also often qualify
ISSN 0009-9236
While human longevity data is still emerging, the mechanistic basis for anti-aging effects is well-established