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Thiamin-responsive pyruvate dehydrogenase complex (PDHC) deficiency Mutations in PDHC prevent the efficient oxidation of carbohydrates in affected individuals

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(PubMed) Stephenson CM, Levin RD, Spector T, Lis CG

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Furthermore, studies indicate its safety for long-term use, highlighting its advantages over other peptides in terms of insulin impact, fat metabolism, and safety