PubMed record Spth-Schwalbe E, Schfer A, Uthgenannt D, Born J, Fehm HL
Here, we find that LDHB promotes GSH synthesis and defends against ferroptosis by upregulating SLC7A11, the functional subunit of the cystine/glutamate antiporter system Xc (SLC7A11 and SLC3A2), which takes up extracellular cystine to synthesize the antiferroptotic metabolite GSH [36, 63], a cofactor of GPX4 that neutralizes lipid peroxides and suppresses ferroptosis [33]
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Glutathione is undoubtedly beneficial for the kidneys with minimal downsides
Across reviews, a recurring theme is improved recovery and wellness, though the exact outcomes vary from person to person