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CPP-CAND disrupts FOXO4-p53 foci and induces apoptosis through caspase-dependent pathways FOXO4 is progressively recruited to euchromatin foci following senescence induction and is retained in the nucleus of senescent cells through its interaction with p53, contributing to the maintenance of the senescent state 34

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Severe cases can lead to dementia and psychosis

[DOI] [PubMed] [Google Scholar] 23.Waligora A.C., Johanson N.A., Hirsch B.E

As a result, it works well for multi-phase tissue research models