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Leuk Res 32(12):1895-1902, 2008

Eur J Neurol 21(2):287e13 Coppola G, Di Renzo A, Tinelli E et al (2016) Thalamo-cortical network activity between migraine attacks: insights from MRI-based microstructural and functional resting-state network correlation analysis

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This sensitization to TGF-beta signaling augments expression of matrix genes including collagens, fibronectin, and proteoglycans, while appropriate regulation prevents excessive TGF-beta activity associated with pathological fibrosis

Copper peptides also demonstrate anti-inflammatory effects that may slow degenerative processes