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Importantly, kids who tested positive for folate receptor antibodies saw the greatest benefits

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Mutation of His 18 to Ala abolished activity, consistent with the central role of His 18 in catalysis

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Beriberi is caused by a deficiency in Thiamine and its symptoms, according to Google Health are: Difficulty walking Loss of feeling (sensation) in hands and feet Loss of muscle function or paralysis of the lower legs Mental confusion/speech difficulties Pain Strange eye movements (nystagmus) Tingling Vomiting Awakening at night short of breath Increased heart rate Shortness of breath with activity Swelling of the lower leg The best treatment for Beriberi is Thiamine supplementation and stop drinking alcohol