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An additional argument is a direct demonstration of the healing of the severely injured muscles (15-17) and severely injured nerves (18) and brain injuries (19-23) not relied on immunomodulation

347,348 Uncoupling of astrocytic syncytia or knocking out Cx43 in experimental models instigates seizures

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Vandewalle J, Luypaert A, De Bosscher K, Libert C

Beyond metabolic benefits, recent studies also indicate that IF may moderate immune dysregulation by influencing critical inflammatory signaling pathways, which could have therapeutic implications for autoimmune diseases [59]