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Clin Drug Investig 32:621639 Ponticelli C, Escoli R, Moroni G (2018) Does cyclophosphamide still play a role in glomerular diseases

One explanation for this discrepancy is that NAD + precursors are likely to be most beneficial when NAD + homeostasis is challenged by insults including a need for drug detoxification, activation of the DNA damage response and altered metabolic flux, as occurs with chemotherapy treatment and/or ageing, but not in unchallenged scenarios where there is no excess demand on the NAD + metabolome

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Most studies report that in humans, NCs disappear when they are about 710 years of age, whereas the age of onset of disc degeneration is 3050 years [8]

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