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Human clinical trials Only two human studies evaluated the effect of glutamine on the lipid profile, and neither resulted in a significant change

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A 2025 meta-analysis of 7 RCTs (n=456) reported standardized mean differences of -0.72 for wrinkles (95% CI -1.02 to -0.42

Surgery is more effective than nonoperative therapy in improving short- and long-term pain, especially if leg symptoms are predominant

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