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Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity

The IgG variants were purified using CaptureSelect C H 1 columns (Thermo Fisher) prior to size exclusion chromatography (SEC) to isolate monomeric fractions using a Superdex 200 Increase 10/300 column (Cytiva Life Sciences) with an KTA Avant 25 (Cytiva Life Sciences)

Exosomes and biomimetic nanoparticles, natural or synthetic vesicles can be targeted to certain cells and are very efficient in transporting siRNAs, mRNAs, and small molecules across the blood-brain barrier