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Thymosin beta-4 exhibits a broader range of biological actions due to its extended sequence and additional regulatory motifs, while TB-500 provides a simplified, targeted model for studying actin-binding and local regeneration processes

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Thus, senescent cells are causal for the reduction in renal function in fast aging Xpd TTD/TTD and naturally aged wildtype mice and by selective targeting of high-SASP expressing senescent cells in the tubuli, FOXO4-DRI can restore kidney homeostasis