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Advanced experimental techniques, including spatial transcriptome, single-cell (or nuclei) transcriptomics and assay for transposase-accessible chromatin using sequencing, will be instrumental in uncovering the epigenetic and transcriptomic signatures associated with the transformation of astrocytes under neurodegenerative conditions 156

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doi: 10.1002/med.21754 20 DiotalleviFGioacchiniHDe SimoniEMaraniACandeloraMPaolinelliMet al

His successors at the FDA, however, appear to be taking a different approach