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Long-term low-dose oral administration of PS-NPs induces excessive generation of reactive oxygen species (ROS), which on one hand triggers an inflammatory response via the NF-B signaling pathway, and on the other hand promotes the expression of the antioxidant gene HO-1 through Nrf2

Strubel, A

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doi: 10.1038/s41581-023-00689-x 17 LongZLuoYYuMWangXZengLYangK

In addition, liver-derived acylcarnitine can also be taken up by intestinal epithelial cells and used for mitochondrial oxidative metabolism, providing additional energy for intestinal cells [218]