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The "minimal initial benefit" group (approximately 5-10% of users) reported limited improvements during treatment making discontinuation effects irrelevant, typically explained by inadequate product quality with degraded or low-concentration GHK-Cu, inappropriate application technique reducing absorption, unrealistic expectations exceeding what any topical can achieve, severe underlying pathology requiring medical intervention beyond cosmetic peptides, or individual non-responsiveness to copper peptide treatment for genetic or physiological reasons

At Dermo Direct, we are frequently asked: What supplements can I take while on isotretinoin? Are there vitamins that help with dryness or side effects? Which supplements should I avoid? As a Dermatologist I often suggest that a lot of oral supplements are not needed whilst taking isotretinoin, as gentle skin care, emollient use and sunscreen/sun protection are the key focus areas for patients taking isotretinoin but if patients are struggling with certain side effects, some of the following supplements can help

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Peptides generally safe based on widespread use reports

Detoxification : Aids in the detoxification of harmful substances and heavy metals in the liver