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The Reuters report on a head-to-head trial against tirzepatide (February 2026) noted CagriSema did not meet a non-inferiority threshold against tirzepatide on average weight loss at 84 weeks

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Known risks and side effects: Injection-site reactions (pain, redness, swelling, and induration) are the most consistently reported adverse effects across CJC-1295's human research and compounded/gray-market use

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