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Yue-Yu Gu, [email protected] These authors have contributed equally to this work This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Mechanistically, riboflavin deficiency leads to diminished glutathione reductase activity, reducing the GSH/GSSG ratio and compromising redox buffering