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sinensis , which may lead to the difference in epidemiology, pathogenicity, and even chemotherapy responsiveness (337)

Research involving ACE-031 has suggested that it may influence these processes through pathways such as ERK1/2 activation, stabilization of mitochondrial function, and reduction in free radical populations

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In this review, we discuss briefly the present understanding of TNF--mediated biology and the current injectable therapies in clinical use, and focus on some of the new therapeutic approaches with oral, small-molecule inhibitors

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