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The evidence base is overwhelmingly preclinical, and there are no completed, published Phase 2 or 3 human efficacy trials only early-stage safety work [9]
In addition, this product has not been approved by the FDA for human use
Implications for therapeutic use The pharmacokinetic differences between SLU-PP-332 and 5-amino-1mq have significant implications for their therapeutic use: Dosing frequency: The rapid absorption and extensive distribution of SLU-PP-332 may allow for less frequent dosing compared to 5-amino-1mq
In addition, low IGF-1 subjects in a study were found to possess up-regulated fatty acid metabolism along with down-regulated GLUT-1 gene (in charge of glucose uptake in erythrocytes, brain endothelial cells, eye, peripheral nerve and also responsible for materno-placental glucose transfer) [210]