As of now, there is a lack of robust clinical trials in humans to conclusively determine its safety and efficacy
However, its use in humans remains challenging because to allergic responses, discomfort at administration sites, and other serious toxic events including hemolysis, nonspecific cytotoxic effects, itching feeling, and hypersensitivity during therapeutic therapy
The 2025 mechanistic work reporting AMY1R and AMY3R dependence is a good example of studies that aim to explain why the compound performs as it does at the receptor system level
Closely related in Tesamorelin, which is an FDA approved drug for a narrow indication: patients with HIV lipodystrophy
When people stop treatment, "rapid weight regain" can happen, a 2026 review of studies found