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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

Consult your healthcare provider before starting any new treatments during pregnancy or breastfeeding

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Inactive ingredients and excipients in B12 supplements often play a more significant role than the vitamin itself