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In addition, they also encode various positive or negative regulatory factors related to pathogenicity, including RBF1, EFG1, and TUP1, as well as genes encoding secreted aspartic acid proteases involved in invading the host endothelial barrier and macrophage phagocytosis (Navarro-Garcia et al., 2001)
That excess insulin triggers a cascade: the ovaries are overstimulated to produce androgens, the hypothalamic-pituitary axis loses its normal rhythm, and ovulation becomes irregular or absent
another MoA of DMF/MMF is the direct inhibition of NF-B signalling
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