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Unlike many single-pathway peptides, GHK-Cu has been observed to interact with multiple biological systems simultaneously collagen regulation, oxidative stress response, immune modulation, and neural regeneration making it a high-value compound for multi-pathway research protocols

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[ 344 ] A study in bioinformatics revealed that 9 crucial genes (CXCL9, TIMP1, PTGS2, ICAM1, CXCL1, MMP9, IL1B, CXCL8, and IL6) are linked to the Mayo score in ulcerative colitis, with BACH1 serving as a vital transcription factor regulating their expression

Then, these proteins underwent western blot analysis and the results manifested significantly elevated expression of HTRA1, STEAP4, and VDAC1 in PTX-resistant cells and DR-EVs ( Figure 2G )