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As with any GH secretagogue, chronic use would be expected to elevate IGF-1 levels

To obtain orthogonal proof that our inhibitors bind to the NADP + -TGR(H) forms, we evaluated their effect on thermal stability of TGR using the thermal shift assay (TSA or differential scanning fluorometry)

10.1038/s42255-020-0243-4 133 RiccardiF.TangrediC.Dal BoM.ToffoliG

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The evidence base is preclinical