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In rare cases, people have experienced side effects associated with allergic reaction or sensitivity

Immune-stimulating peptides should be approached with particular caution, and any signs of increased disease activity should prompt immediate protocol review

A 2024 critical review noted that unexpectedly high B12 levels can be further investigated by a clinician if needed, preferably by directly measuring the carrier proteins haptocorrin and transcobalamin rather than relying on the commonly ordered PEG precipitation test, which the authors found nonspecific and potentially misleading (Fedosov, 2024)

Rovin S, Costich ER, Gordon HA

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