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Conflicts of interest Frhbeck G received honoraria from Lilly, Novo Nordisk, Regeneron, AstraZeneca and Boehringer Ingelheim as a member of advisory boards, and honoraria for lectures as a member of the OPEN Spain Initiative

Rarely, complications such as infection or color changes in the skin may occur

Therefore, the tissue-specific effects of l-carnitine are likely to be different among species, and thus more low-carnitine animal models should be established to intensively evaluate the possible different functions of l-carnitine among species

- Keep detailed records of usage and storage as per UK research regulations