In preclinical models this dual mechanism produced greater weight loss than a maximal semaglutide dose, and in a Phase 2 diabetes trial higher survodutide doses reduced weight more than semaglutide though human superiority has not been formally established in head-to-head registration trials
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P-glycoprotein is expressed in intestinal mucosa, renal proximal tubules & in capillary endothelial cells comprising the blood-brain-barrier, and in tumor cells (where it functions as a multi-drug resistance mechanism)
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Contributions to Non-cell Autonomous Impact of ATXN3 Misfolding: Axonal Transport and Neurotransmission Proper neuronal function, survival, and communication require axonal transport as well as intact neurotransmission
